Pathophysiology of hepatitis C virus infection.

J. Camps, J. Córdoba, J. I. Esteban

Research output: Contribution to journalReview articleResearchpeer-review

1 Citation (Scopus)

Abstract

Any physiopathological hypothesis of HCV infection must explain at least some of the most characteristic features of this infection, namely: 1) persistent infection in the majority of exposed individuals, associated with a wide spectrum of histological damages and fluctuating biochemical expression; 2) low tendency towards spontaneous recovery; 3) high tendency to progress to cirrhosis; 4) high prevalence of autoimmune phenomenons; 5) very weak or absent immunity to reinfection. A model is given taking into account the nature of the HCV genome, the immune response of the host to the infection and the potential mechanisms(s) involved in viral persistence.
Original languageEnglish
Pages (from-to)691-702
JournalPathologie Biologie
Volume43
Issue number8
Publication statusPublished - 1 Jan 1995

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