Pathophysiology of electrical storms in the brain of patients with acute brain injury. Preliminary results of a pilot study

J. Sahuquillo Barris, M. Sueiras, B. García-Ĺopez, M. A. Merino, T. Martínez-Valverde, F. Martínez-Ricarte, R. Torné, E. Cobos, M. A. Poca, M. Fabricius

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    The phenomena of cortical spreading depolarization (CSD and CSD-like phenomena) are cellular depolarization waves involved in the progression of lesions in patients with stroke and traumatic brain injury (TBI). Which are detected by an electrocorticographic (ECoG) recording. Experimentally, CSD induces cerebral hypoxia and increases the permeability of the blood-brain barrier. Objectives: To determine the frequency and duration of CSD episodes in patients with TBI and malignant middle cerebral artery infarction (MMCAI) requiring craniectomy. Material and methods: 20 patients were included. A strip of 6 electrodes was placed in the perilesional cortex. Analysis of the number and duration of CSD episodes in the ECoG recording was performed. Results: In four, of the eight ECoG recordings that was fully analyzed, CSD or CSD-like phenomena were identified with a variable frequency and duration. Conclusions: Episodes of CSD and CSD-like phenomena are frequently detected in patients with MMCAI and TBI.
    Original languageEnglish
    Pages (from-to)272-280
    JournalTrauma (Spain)
    Volume22
    Issue number4
    Publication statusPublished - 1 Oct 2011

    Keywords

    • Brain metabolism
    • Brain tissue oxygen pressure
    • Cortical spreading depression
    • ECoG
    • Malignant middle cerebral artery infarction
    • Microdialysis
    • Traumatic brain injury

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