Patch testing with a textile dye mix - A multicentre study

Kristina Ryberg, Tove Agner, Klaus E. Andersen, Andreas Bircher, Thomas Diepgen, Caterina Foti, Ana Giménez-Arnau, Margarida Gonçalo, An Goossens, Jeanne D. Johansen, Christophe Le Coz, Howard I. Maibach, Magnus Bruze

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    13 Citations (Scopus)


    © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Summary Background Disperse dyes are well-known contact sensitizers. However, they are not included in the majority of commercially available baseline patch test series. Objectives To investigate the outcome of patch testing with a textile dye mix (TDM) consisting of eight disperse dyes at dermatology clinics in various countries. Patients/materials/methods Two thousand nine hundred and seven consecutive dermatitis patients at 12 dermatology clinics representing nine countries were tested with a TDM at 6.6%, consisting of Disperse Blue 35, Disperse Yellow 3, Disperse Orange 1 and 3, and Disperse Red 1 and 17, all at 1.0%, and Disperse Blue 106 and Disperse Blue 124, each at 0.3%, provisionally included in the baseline series. Eighty-seven per cent of the patients allergic to the TDM were also tested with the eight separate dyes. Results Contact allergy to TDM was found in 108 patients (3.7%). The frequency of contact allergy varied from 2.1% to 6.9% in different centres. Simultaneous reactivity to p-phenylenediamine was found in 57 of the TDM-positive patients (53%). The most frequent dye allergen among the TDM-positive patients was Disperse Orange 3. The contact allergy could have explained or contributed to the dermatitis in approximately one-third of the patients for whom clinical relevance of the TDM contact allergy was recorded. Conclusions The TDM should be considered for inclusion in the European baseline series.
    Original languageEnglish
    Pages (from-to)215-223
    JournalContact Dermatitis
    Issue number4
    Publication statusPublished - 1 Jan 2014


    • contact allergy
    • disperse dyes
    • Disperse Orange 3
    • p -phenylenediamine
    • patch testing
    • simultaneous reactivity
    • textile dye mix


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