TY - JOUR
T1 - Parvovirus B19 Myocarditis: Looking Beyond the Heart
AU - Izquierdo-Blasco, Jaume
AU - Salcedo Allende, María Teresa
AU - Codina Grau, Maria Gemma
AU - Gran, Ferran
AU - Martínez Sáez, Elena
AU - Balcells, Joan
PY - 2019/1/1
Y1 - 2019/1/1
N2 - © 2019, Society for Pediatric Pathology All rights reserved. Human parvovirus B19 represents the most common etiology of myocarditis in the pediatric population. Although it usually causes a benign exanthematic viral infection, parvovirus B19 may also present as disseminated disease with tropism for the myocardium, causing heart failure with high mortality. We present the case of a 2-year-old patient with fulminating acute myocarditis in whom the histological, immunophenotypic, and microbiological findings in necropsy showed multiorgan involvement caused by parvovirus B19. The autopsy revealed changes due to infection with parvovirus B19 as well as hypoxic-ischemic and secondary autoimmune changes. Medullary aplasia was observed, transmural lymphocyte myocarditis, lymphocytosis in the dermis with endothelial cells positive for parvovirus B19 in immunohistochemistry, cholestatic hepatitis due to ischemia and autoimmune hepatitis, lymphadenitis, and signs of hemophagocytosis. We also found hypoxic-ischemic encephalopathy.
AB - © 2019, Society for Pediatric Pathology All rights reserved. Human parvovirus B19 represents the most common etiology of myocarditis in the pediatric population. Although it usually causes a benign exanthematic viral infection, parvovirus B19 may also present as disseminated disease with tropism for the myocardium, causing heart failure with high mortality. We present the case of a 2-year-old patient with fulminating acute myocarditis in whom the histological, immunophenotypic, and microbiological findings in necropsy showed multiorgan involvement caused by parvovirus B19. The autopsy revealed changes due to infection with parvovirus B19 as well as hypoxic-ischemic and secondary autoimmune changes. Medullary aplasia was observed, transmural lymphocyte myocarditis, lymphocytosis in the dermis with endothelial cells positive for parvovirus B19 in immunohistochemistry, cholestatic hepatitis due to ischemia and autoimmune hepatitis, lymphadenitis, and signs of hemophagocytosis. We also found hypoxic-ischemic encephalopathy.
KW - children
KW - extracorporeal membrane oxygenation treatment
KW - hepatitis
KW - multiple organ dysfunction syndrome
KW - myocarditis
KW - parvovirus B19
U2 - 10.1177/1093526619865641
DO - 10.1177/1093526619865641
M3 - Article
C2 - 31335286
SN - 1093-5266
JO - Pediatric and Developmental Pathology
JF - Pediatric and Developmental Pathology
ER -
