Participation of Monocytes and Macrophages in Canine Glomerular Disease

M. Vilafranca; L. Ferrer; P. Wohlsein; G. Trautwein

doi:10.1111/j.1439-0442.1994.tb00148.x

Participation of Monocytes and Macrophages in Canine Glomerular Disease

M. Vilafranca, L. Ferrer, P. Wohlsein, G. Trautwein

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

The presence of monocytes/macrophages (MPs) in renal glomeruli was investigated in 86 dogs with different types of glomerulopathies. The identification of MPs in tissue sections was based on cytological criteria and the immunohistochemical demonstration of lysozyme. The highest numbers of MPs in glomeruli were observed in focal and diffuse mesangial proliferative glomerulonephritis (MesPGN), diffuse endocapillary proliferative glomerulonephritis (DEPGN), and diffuse mesangiocapillary glomerulonephritis (DMCGN). In cases of minor glomerular abnormalities (MGA), focal and segmental hyalinosis and sclerosis (FGS), diffuse membranous glomerulonephritis (DMemGN), and diffuse sclerosing glomerulonephritis (DSGN) the presence of glomerular MPs was low. Particularly in MesPGN, the number of MPs was correlated with glomerular hypercellularity and, additionally in DMCGN, with the degree of proteinuria. The results of this study suggest that MPs may be involved in functional and morphological alterations in different types of canine glomerulopathies. © 1994 Blackwell Verlag GmbH

Original language	English
Pages (from-to)	770-779
Journal	Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine
Volume	41
Issue number	1-10
DOIs	https://doi.org/10.1111/j.1439-0442.1994.tb00148.x
Publication status	Published - 1 Jan 1994

Access to Document

10.1111/j.1439-0442.1994.tb00148.x

Cite this

@article{bd4595cde99c4f59938b554f7db924bc,

title = "Participation of Monocytes and Macrophages in Canine Glomerular Disease",

abstract = "The presence of monocytes/macrophages (MPs) in renal glomeruli was investigated in 86 dogs with different types of glomerulopathies. The identification of MPs in tissue sections was based on cytological criteria and the immunohistochemical demonstration of lysozyme. The highest numbers of MPs in glomeruli were observed in focal and diffuse mesangial proliferative glomerulonephritis (MesPGN), diffuse endocapillary proliferative glomerulonephritis (DEPGN), and diffuse mesangiocapillary glomerulonephritis (DMCGN). In cases of minor glomerular abnormalities (MGA), focal and segmental hyalinosis and sclerosis (FGS), diffuse membranous glomerulonephritis (DMemGN), and diffuse sclerosing glomerulonephritis (DSGN) the presence of glomerular MPs was low. Particularly in MesPGN, the number of MPs was correlated with glomerular hypercellularity and, additionally in DMCGN, with the degree of proteinuria. The results of this study suggest that MPs may be involved in functional and morphological alterations in different types of canine glomerulopathies. {\textcopyright} 1994 Blackwell Verlag GmbH",

author = "M. Vilafranca and L. Ferrer and P. Wohlsein and G. Trautwein",

year = "1994",

month = jan,

day = "1",

doi = "10.1111/j.1439-0442.1994.tb00148.x",

language = "English",

volume = "41",

pages = "770--779",

number = "1-10",

}

TY - JOUR

T1 - Participation of Monocytes and Macrophages in Canine Glomerular Disease

AU - Vilafranca, M.

AU - Ferrer, L.

AU - Wohlsein, P.

AU - Trautwein, G.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The presence of monocytes/macrophages (MPs) in renal glomeruli was investigated in 86 dogs with different types of glomerulopathies. The identification of MPs in tissue sections was based on cytological criteria and the immunohistochemical demonstration of lysozyme. The highest numbers of MPs in glomeruli were observed in focal and diffuse mesangial proliferative glomerulonephritis (MesPGN), diffuse endocapillary proliferative glomerulonephritis (DEPGN), and diffuse mesangiocapillary glomerulonephritis (DMCGN). In cases of minor glomerular abnormalities (MGA), focal and segmental hyalinosis and sclerosis (FGS), diffuse membranous glomerulonephritis (DMemGN), and diffuse sclerosing glomerulonephritis (DSGN) the presence of glomerular MPs was low. Particularly in MesPGN, the number of MPs was correlated with glomerular hypercellularity and, additionally in DMCGN, with the degree of proteinuria. The results of this study suggest that MPs may be involved in functional and morphological alterations in different types of canine glomerulopathies. © 1994 Blackwell Verlag GmbH

AB - The presence of monocytes/macrophages (MPs) in renal glomeruli was investigated in 86 dogs with different types of glomerulopathies. The identification of MPs in tissue sections was based on cytological criteria and the immunohistochemical demonstration of lysozyme. The highest numbers of MPs in glomeruli were observed in focal and diffuse mesangial proliferative glomerulonephritis (MesPGN), diffuse endocapillary proliferative glomerulonephritis (DEPGN), and diffuse mesangiocapillary glomerulonephritis (DMCGN). In cases of minor glomerular abnormalities (MGA), focal and segmental hyalinosis and sclerosis (FGS), diffuse membranous glomerulonephritis (DMemGN), and diffuse sclerosing glomerulonephritis (DSGN) the presence of glomerular MPs was low. Particularly in MesPGN, the number of MPs was correlated with glomerular hypercellularity and, additionally in DMCGN, with the degree of proteinuria. The results of this study suggest that MPs may be involved in functional and morphological alterations in different types of canine glomerulopathies. © 1994 Blackwell Verlag GmbH

U2 - 10.1111/j.1439-0442.1994.tb00148.x

DO - 10.1111/j.1439-0442.1994.tb00148.x

M3 - Article

VL - 41

SP - 770

EP - 779

IS - 1-10

ER -

Participation of Monocytes and Macrophages in Canine Glomerular Disease

Abstract

Access to Document

Fingerprint

Cite this