Partial lack of BCL2 in follicular lymphoma: An unusual immunohistochemical staining pattern explained by ongoing BCL2 mutation

Michiel van den Brand, Mar Garcia-Garcia, Janneke J.M. Mathijssen, Lluis Colomo, Patricia J.T.A. Groenen, Sergio Serrano, J. Han J.M. van Krieken

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

© 2015 Elsevier GmbH. Follicular lymphomas are characterized by overexpression of BCL2 which, in the large majority of cases, is due to a t(14;18) translocation which juxtaposes the BCL2 locus to the immunoglobulin heavy chain locus (IGH). Here, we report partial absence of BCL2 immunohistochemical staining in a case of FL, due to a mutation in the part of BCL2 that encodes the epitope for the most frequently used antibody against BCL2. This finding shows that mutations in BCL2 occur in an ongoing process in follicular which can give rise to unusual immunohistochemical staining patterns.
Original languageEnglish
Pages (from-to)148-150
JournalPathology Research and Practice
Volume212
Issue number2
DOIs
Publication statusPublished - 1 Feb 2016

Keywords

  • BCL2
  • Follicular lymphoma
  • Immunohistochemistry

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