PARS: A web server for the prediction of Protein Allosteric and Regulatory Sites

Alejandro Panjkovich, Xavier Daura

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Abstract

Summary: The regulation of protein activity is a key aspect of life at the molecular level. Unveiling its details is thus crucial to understanding signalling and metabolic pathways. The most common and powerful mechanism of protein-function regulation is allostery, which has been increasingly calling the attention of medicinal chemists due to its potential for the discovery of novel therapeutics. In this context, PARS is a simple and fast method that queries protein dynamics and structural conservation to identify pockets on a protein structure that may exert a regulatory effect on the binding of a small-molecule ligand. © The Author 2013. Published by Oxford University Press.
Original languageEnglish
Pages (from-to)1314-1315
JournalBioinformatics
Volume30
Issue number9
DOIs
Publication statusPublished - 1 May 2014

Fingerprint Dive into the research topics of 'PARS: A web server for the prediction of Protein Allosteric and Regulatory Sites'. Together they form a unique fingerprint.

Cite this