Paradox of enrichment and system order reduction: Bacteriophages dynamics as case study

Andrei Korobeinikov, Elena Shchepakina, Vladimir Sobolev

    Research output: Contribution to journalArticleResearchpeer-review

    12 Citations (Scopus)

    Abstract

    © The authors 2015. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved. The paradox of enrichment in a 3D model for bacteriophage dynamics, with a free infection stage of the phage and a bilinear incident rate, is considered. An application of the technique of singular perturbation theory allows us to demonstrate why the paradox arises in this 3D model despite the fact that it has a bilinear incident rate (while in 2D predator-prey models it is usually associated with the concavity of the attack rate). Our analysis demonstrates that the commonly applied approach of the model order reduction using the so-called quasi-steady-state approximation can lead to a loss of important properties of an original system.
    Original languageEnglish
    Article numberdqv025
    Pages (from-to)359-369
    JournalMathematical Medicine and Biology
    Volume33
    Issue number3
    DOIs
    Publication statusPublished - 1 Sep 2016

    Keywords

    • Bacteriophage
    • Hopf bifurcation
    • Limit cycle
    • Model order reduction
    • Self-sustained oscillations
    • Singular perturbations
    • Stability
    • The paradox of enrichment

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