Paracrine network: Another step in the complexity of resistance to EGFR blockade?

Ramon Salazar, Gabriel Capellà, Josep Tabernero

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

©2014 American Association for Cancer Research. Increased secretion of EGFR ligands amphiregulin and TGFa by limited KRAS-mutant clones is suggested as a paracrine resistance mechanism to anti-EGFR antibodies in colorectal cancer models. These findings are biologically sound but need to be replicated, including in the clinical setting, to foresee whether they are clinically relevant and therapeutically exploitable.
Original languageEnglish
Pages (from-to)6227-6229
JournalClinical Cancer Research
Volume20
Issue number24
DOIs
Publication statusPublished - 15 Dec 2014

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