Panic/phobic anxiety in schizophrenia: A positive association with joint hypermobility syndrome

Antonio Bulbena, B. Anguiano, J. Gago, E. Basterreche, J. Ballesteros, I. Eguiluz, M. A. González Torres, D. P. Reddy, J. D. Coplan, G. E. Berrios

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    7 Citations (Scopus)


    Background: To study the rate of comorbidity between panic/phobic anxiety conditions and schizophrenia and ascertain whether the reported link between the anxiety disorders and the Joint Hypermobility Syndrome (JHS) still holds in the presence of schizophrenia. Methods: The authors blindly assessed presence of comorbid panic/phobic cluster disorders and prevalence of JHS in 124 outpatients with established schizophrenia. Results: Nearly 30% of patients with schizophrenia were positive for a panic/phobic anxiety disorder (13.7% panic/agoraphobia, 10.5% social phobia and 5.6% simple phobia). Using Beighton's criteria, JHS was markedly more frequent amongst the schizophrenic-panic/phobic cluster (62.1%) than in the non-comorbid group (14.9%) [OR: 9.35, CI: 3.85-22.73, p<0.0001]. The panic/phobic cluster showed increased scores on fear and positive symptom scales. Conclusion: In patients with schizophrenia, the association between JHS and the panic/phobic cluster of anxiety disorders seems to persistent. © Universitätsverlag Ulm GmbH 2005.
    Original languageEnglish
    Pages (from-to)95-100
    JournalNeurology Psychiatry and Brain Research
    Issue number2
    Publication statusPublished - 7 Dec 2005


    • Agoraphobia
    • Joint hypermobility syndrome
    • Panic
    • Schizophrenia
    • Social phobia


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