Panic disorder and personality disorder comorbidity

R Navinés, E Egmon, C Binelli, S Subirà, J Obiols, R. Martín-Santos, Antonio Egidio Nardi (Editor), Rafael Christophe R Freire (Editor)

Research output: Chapter in BookChapterResearchpeer-review


© Springer International Publishing Switzerland 2016. The present chapter systematically reviews the relationship between panic disorder, with and without co-occurring anxiety or depression, and current personality disorder. Data were collected with an advanced document protocol according to MOOSE (Meta-analysis of Observational Studies in Epidemiology) guidelines for observational studies. A comprehensive, computerized literature search was conducted in Medline, PsycINFO, and LILACS. Cohort, case-control and cross-sectional surveys studies evaluating the comorbidity between DSM panic disorder and personality disorders were included. Overall prevalence, comorbidity rates, and 95 % CI were calculated with a random effects model. From 97 initial selected papers, 24 entered in the review. Among patients with a current DSM- III/R/IV panic disorder, 44.3 % (34.6- 54.2 %) had any personality disorder; 6.3 % (3.1-10.4 %) had cluster A; 17.9 % (12.2- 24.2 %) cluster B, and 34.9 % (25.6-44.7 %) had cluster C. Among patients with a current panic disorder and co-occurring anxiety or depression, 61.8 % (44.6-77.7 %) had any personality disorder, 7.2 % (4.4-10.5 %) had cluster A; 24.0 % (17.6-30.9 %) cluster B, and 38.6 % (25.7-52.2 %) had cluster C. In conclusion, comorbidity between panic disorder and personality disorders is common. Cluster C was the most frequent personality disorder subtype related to panic disorder. Personality disorders were more prevalent among individuals with panic disorder and co-occurring anxiety or depression.
Original languageEnglish
Title of host publicationPanic Disorder: Neurobiological and treatment aspects
Number of pages15
Publication statusPublished - 1 Jan 2016


  • Cluster A
  • Cluster B
  • Cluster C
  • Depression comorbidity
  • Panic disorder
  • Personality disorder
  • Systematic review
  • Treatment non-responders


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