P21(WAF1/Cip1) expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx

A Nadal, P Jares, M Cazorla, PL Fernandez, G. Sanjuan, L Hernandez, M Pinyol, M Aldea, C Mallofre, J Muntane, J Traserra, E Campo, A Cardesa

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Abstract

p21(WAF1/Cip1) is a recently identified gene involved in cell cycle regulation through cyclin-CDK-complex inhibition. The expression of this gene in several cell lines stems to be induced by wild-type, but not mutant, p53, p21(WAF1/Cip1) expression has been studied at both mRNA and protein levels in a series of 49 normal mucosae and squamous cell carcinomas of the larynx, A significant association was found between mRNA and protein expression in tumours (P

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalJ. Pathol.
Volume183
Issue number2
Publication statusPublished - Oct 1997

Keywords

  • p21(WAF1/Cip1)
  • p53
  • larynx
  • squamous cell carcinoma
  • differentiation
  • P53-INDEPENDENT EXPRESSION
  • PROTEIN OVEREXPRESSION
  • TUMOR SUPPRESSION
  • GENE-MUTATIONS
  • INHIBITOR
  • P21
  • INDUCTION
  • ABSENCE
  • CYCLINS
  • KINASES

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