P16Ink4a overexpression in cancer: A tumor suppressor gene associated with senescence and high-grade tumors

C. Romagosa, S. Simonetti, L. López-Vicente, A. Mazo, M. E. Lleonart, J. Castellvi, S. Ramon Y. Cajal

Research output: Contribution to journalReview articleResearchpeer-review

271 Citations (Scopus)

Abstract

p16Ink4a is a protein involved in regulation of the cell cycle. Currently, p16Ink4a is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors. Intriguingly, overexpression of p16Ink4a has also been described in several tumors. This review attempts to elucidate when and why p16Ink4a overexpression occurs, and to suggest possible implications of p16Ink4a in the diagnosis, prognosis and treatment of cancer. © 2011 Macmillan Publishers Limited All rights reserved.
Original languageEnglish
Pages (from-to)2087-2097
JournalOncogene
Volume30
Issue number18
DOIs
Publication statusPublished - 5 May 2011

Keywords

  • cancer
  • high grade
  • overexpression
  • p16 Ink4a
  • senescence

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