Oxidized limonene and oxidized linalool - Concomitant contact allergy to common fragrance terpenes

Johanna Bråred Christensson, Ann Therese Karlberg, Klaus E. Andersen, Magnus Bruze, Jeanne D. Johansen, Begoña Garcia-Bravo, Ana Giménez Arnau, Chee Leok Goh, Rosemary Nixon, Ian R. White

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31 Citations (Scopus)


© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Summary Background Limonene and linalool are common fragrance terpenes. Both oxidized R-limonene and oxidized linalool have recently been patch tested in an international setting, showing contact allergy in 5.2% and 6.9% of dermatitis patients, respectively. Objective To investigate concomitant reactions between oxidized R-limonene and oxidized linalool in consecutive dermatitis patients. Methods Oxidized R-limonene 3.0% (containing limonene hydroperoxides 0.33%) and oxidized linalool 6% (linalool hydroperoxides 1%) in petrolatum were tested in 2900 consecutive dermatitis patients in Australia, Denmark, Singapore, Spain, Sweden, and the United Kingdom. Results A total of 281 patients reacted to either oxidized R-limonene or oxidized linalool. Of these, 25% had concomitant reactions to both compounds, whereas 29% reacted only to oxidized R-limonene and 46% only to oxidized linalool. Of the 152 patients reacting to oxidized R-limonene, 46% reacted to oxidized linalool, whereas 35% of the 200 patients reacting to oxidized linalool also reacted to oxidized R-limonene. Conclusions The majority of the patients (75%) reacted to only one of the oxidation mixtures, thus supporting the specificity of the reactions. The concomitant reactions to the two fragrance allergens suggest multiple sensitizations, which most likely reflect the exposure to the different fragrance materials in various types of consumer products. This is in accordance with what is generally seen for patch test reactions to fragrance materials.
Original languageEnglish
Pages (from-to)273-280
JournalContact Dermatitis
Issue number5
Publication statusPublished - 1 May 2016


  • allergic contact dermatitis
  • autoxidation
  • concomitant reactions
  • fragrance allergy
  • hydroperoxides
  • limonene
  • linalool
  • oxidation products
  • patch test concentration
  • patch testing


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