Oxidative additions of aryl halides to palladium proceed through the monoligated complex

Krista Vikse, Tsuki Naka, J. Scott McIndoe, Maria Besora, Feliu Maseras

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Abstract

Palladium(0) complexes facilitate many catalytic transformations that begin with the oxidative addition of a halobenzene. The ligation state of the palladium during this reaction is a vexing issue, owing to the inherent difficulty of isolating reactive, coordinatively unsaturated metal complexes. By isolating them in the gas phase in an ion-trap mass spectrometer, the reactivity of mono- and bisligated palladium complexes can be directly compared, and the former proved to be several orders of magnitude more reactive towards halobenzenes. Calculations of barrier heights for the oxidative addition led to additional experiments, which demonstrated that although the reaction proceeded to completion for iodobenzene, the reaction was slower for bromobenzene and progressed only as far as an ion-molecule adduct for chloro- and fluorobenzene. Seeing the real catalyst: A combination of mass spectrometry experiments and DFT calculations on the reactivity of halobenzenes with mono- and bisligated palladium complexes allows a direct comparison of energy barriers to the oxidative addition process, and, consequently a direct peek into the intrinsic reactivity of the metal complexes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)3604-3609
JournalChemCatChem
Volume5
Issue number12
DOIs
Publication statusPublished - 1 Dec 2013

Keywords

  • cross-coupling
  • density functional calculations
  • halides
  • mass spectrometry
  • palladium

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