Overexpression of the nuclear factor-kappa B (p65) in association with local failure in patients with head and neck carcinoma undergong radiotherapy or chemoradiotherapy

Ana Quintana, Francesc X. Avilés, Ximena Terra, Sonia Alcolea, Mercedes Camacho, Miquel Quer, Luis Vila, Xavier León

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9 Citations (Scopus)

Abstract

Background The aim of this study was to evaluate nuclear factor-kappa B (NF-κB) expression as a biologic marker to predict local control in patients with head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy or chemoradiotherapy. Methods The mRNA expression levels of the NF-κB family genes were determined with real-time-polymerase chain reaction in 77 patients with HNSCC treated with radiotherapy or chemoradiotherapy. Results The mRNA NF-κB (p65) expression in pretreatment tumors was significantly related to local control (p =.03). The 5-year local recurrence-free survival rate in patients with low-level NF-κB (p65) expression (n = 42) was 79.9%, and in patients with a high level of expression it was 42.1% (p =.001). In a multivariate analysis, the mRNA NF-κB (p65) expression level was the only variable related to local control of the tumor. Conclusion Expression of the NF-κB (p65) gene may be a radiosensitivity marker for patients with a HNSCC. © 2012 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)370-375
JournalHead and Neck
Volume35
Issue number3
DOIs
Publication statusPublished - 1 Mar 2013

Keywords

  • head and neck squamous cell carcinoma
  • nuclear factor kappa B
  • p65
  • radiosensitivity
  • real-time-polymerase chain reaction

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