© 2017 Abdesselem Boulkroune et al. This paper solves the problem of projective lag-synchronization based on output-feedback control for chaotic drive-response systems with input dead-zone and sector nonlinearities. This class of the drive-response systems is assumed in Brunovsky form but with unavailable states and unknown dynamics. To effectively deal with both dead-zone and sector nonlinearities, the proposed controller is designed in a variable-structure framework. To online learn the uncertain dynamics, adaptive fuzzy systems are used. And to estimate the unavailable states, a simple synchronization error is constructed. To prove the stability of the overall closed-loop system (controller, observer, and drive-response system) and to design the adaptation laws, a Lyapunov theory and strictly positive real (SPR) approach are exploited. Finally, three academic examples are given to show the effectiveness of this proposed lag-synchronization scheme.