TY - JOUR
T1 - Organochlorine pesticides and polychlorinated biphenyls (PCBs) in early adulthood and blood lipids over a 23-year follow-up
AU - Suarez-Lopez, Jose R.
AU - Clemesha, Chase G.
AU - Porta, Miquel
AU - Gross, Myron D.
AU - Lee, Duk Hee
PY - 2019/2/1
Y1 - 2019/2/1
N2 - © 2018 Elsevier B.V. Background: Some evidence in humans suggests that persistent organic pollutants (POPs), including organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), may alter the blood lipid composition. This study analyzed associations between serum POPs concentrations in young adulthood with blood lipid levels up to 23 years later. Methods: Serum POPs were measured in year 2 of follow-up (n = 180 men and women, ages: 20-32y), and plasma lipids in follow-up years 2, 7, 10, 15, 20 and 25. 32 POPs were detectable in ≥75% of participants (23 PCBs, 8 OCPs and PBB-153). We created summary scores for PCBs and OCPs for both wet-weight, and lipid standardized (LP) concentrations. We used repeated measures regression adjusting for demographic factors, BMI, smoking, diabetes status, among others. Results: We observed positive associations of the 23 LP-PCB score with total cholesterol (β per SD increase [95%CI]: 5.0 mg/dL [0.7, 9.2]), triglycerides (7.8 mg/dL [-0.9, 16.5]), LDL (4.2 mg/dL [0.2, 8.2]), oxidized LDL 3.4 U/L (-0.05, 6.8), and cholesterol/HDL ratio (0.2 [0.02, 0.3]). The associations for triglycerides (14.7 mg/dL [0.4, 20.1]), cholesterol/HDL (0.33 [0.09, 0.56]) and, to some extent, LDL (4.7 md/dL [-1.6, 10.9]) were only observed among participants in the upper 50th percentile of BMI. Non-dioxin-like PCBs had stronger associations that dioxin-like PCBs. OCPs and PBB-s had positive associations with most outcomes. Conclusions: PCBs and PBB-153 measured in young adulthood were positively associated with prospective alterations in most blood lipid components, with evidence of effect modification by BMI. Further longitudinal studies with multiple measures of POPs overtime are needed.
AB - © 2018 Elsevier B.V. Background: Some evidence in humans suggests that persistent organic pollutants (POPs), including organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), may alter the blood lipid composition. This study analyzed associations between serum POPs concentrations in young adulthood with blood lipid levels up to 23 years later. Methods: Serum POPs were measured in year 2 of follow-up (n = 180 men and women, ages: 20-32y), and plasma lipids in follow-up years 2, 7, 10, 15, 20 and 25. 32 POPs were detectable in ≥75% of participants (23 PCBs, 8 OCPs and PBB-153). We created summary scores for PCBs and OCPs for both wet-weight, and lipid standardized (LP) concentrations. We used repeated measures regression adjusting for demographic factors, BMI, smoking, diabetes status, among others. Results: We observed positive associations of the 23 LP-PCB score with total cholesterol (β per SD increase [95%CI]: 5.0 mg/dL [0.7, 9.2]), triglycerides (7.8 mg/dL [-0.9, 16.5]), LDL (4.2 mg/dL [0.2, 8.2]), oxidized LDL 3.4 U/L (-0.05, 6.8), and cholesterol/HDL ratio (0.2 [0.02, 0.3]). The associations for triglycerides (14.7 mg/dL [0.4, 20.1]), cholesterol/HDL (0.33 [0.09, 0.56]) and, to some extent, LDL (4.7 md/dL [-1.6, 10.9]) were only observed among participants in the upper 50th percentile of BMI. Non-dioxin-like PCBs had stronger associations that dioxin-like PCBs. OCPs and PBB-s had positive associations with most outcomes. Conclusions: PCBs and PBB-153 measured in young adulthood were positively associated with prospective alterations in most blood lipid components, with evidence of effect modification by BMI. Further longitudinal studies with multiple measures of POPs overtime are needed.
KW - Adults
KW - Lipids
KW - Longitudinal
KW - Organochlorine
KW - PCB
KW - Humans
KW - Middle Aged
KW - Male
KW - Environmental Exposure
KW - Hydrocarbons, Chlorinated/blood
KW - Case-Control Studies
KW - Young Adult
KW - Adult
KW - Female
KW - Pesticides/blood
KW - Lipids/blood
UR - http://www.mendeley.com/research/organochlorine-pesticides-polychlorinated-biphenyls-pcbs-early-adulthood-blood-lipids-23year-followu
U2 - 10.1016/j.etap.2018.12.018
DO - 10.1016/j.etap.2018.12.018
M3 - Article
C2 - 30594847
SN - 1382-6689
VL - 66
SP - 24
EP - 35
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
ER -