Orchiectomy affects the hypothalamo-pituitary-adrenal axis in a complex way. It increases adrenocorticotrophin (ACTH) secretion but reduces both the basal levels and ACTH-stimulated secretion of corticosteroids in vivo and in vitro. In addition, orchiectomy decreases the half life of plasma corticosterone and increases the hepatic reduction of its A-ring, in spite of corticosterone-binding globulin (CBG) being elevated in orchiectomized rats. However, basal corticosterone and adrenocortical responses to ether induced stress are not modified in orchiectomized rats in comparison with unoperated male animals. In the present work we have studied the effect of gonadectomy in adult rats on the adrenocortical response to different periods of noise stress.
|Journal||IRCS Medical Science|
|Publication status||Published - 1 Jan 1982|