Orchiectomy does not modify the adrenocortical response to noise stress in the rat

A. Armario, J. M. Castellanos, J. Balasch

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Orchiectomy affects the hypothalamo-pituitary-adrenal axis in a complex way. It increases adrenocorticotrophin (ACTH) secretion but reduces both the basal levels and ACTH-stimulated secretion of corticosteroids in vivo and in vitro. In addition, orchiectomy decreases the half life of plasma corticosterone and increases the hepatic reduction of its A-ring, in spite of corticosterone-binding globulin (CBG) being elevated in orchiectomized rats. However, basal corticosterone and adrenocortical responses to ether induced stress are not modified in orchiectomized rats in comparison with unoperated male animals. In the present work we have studied the effect of gonadectomy in adult rats on the adrenocortical response to different periods of noise stress.
Original languageEnglish
Pages (from-to)791
JournalIRCS Medical Science
Volume10
Issue number10
Publication statusPublished - 1 Jan 1982

Fingerprint Dive into the research topics of 'Orchiectomy does not modify the adrenocortical response to noise stress in the rat'. Together they form a unique fingerprint.

Cite this