Oral glutamine challenge and magnetic resonance spectroscopy in three patients with congenital portosystemic shunts

María Ortiz, Juan Córdoba, Juli Alonso, Alex Rovira, Sergi Quiroga, Carlos Jacas, Rafael Esteban, Jaume Guardia

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31 Citations (Scopus)

Abstract

Background/Aims: Congenital portosystemic shunts are rare abnormalities of liver vasculature that can cause neurological symptoms, probably secondarily to the effects of the metabolism of ammonia in the brain. Our aim was to investigate the relationship between capillary blood ammonia after oral glutamine challenge and magnetic resonance spectroscopy in three patients with congenital portosystemic shunts. Methods: Neuropsychological tests, oral glutamine challenge and magnetic resonance spectroscopy were performed at baseline and after 6 months of follow-up in three patients with congenital portosystemic shunts. The results were compared to those obtained in a group of six cirrhotic patients with prior episodes of hepatic encephalopathy and healthy controls. Results: Patients with congenital portosystemic shunts exhibited abnormalities of neuropsychological tests, magnetic resonance spectroscopy and a response to the oral glutamine challenge similar to those observed in patients with cirrhosis. The intensity of the rise of brain glutamine was correlated to the area under the curve of ammonia after the oral glutamine challenge (R=0.72). Conclusions: Neurological manifestations of patients with congenital portosystemic shunts are mediated through similar mechanisms that are involved in the pathogenesis of hepatic encephalopathy. The area under the curve appears to be the better parameter that defines the response to the oral glutamine challenge. © 2004 Published by Elsevier B.V. on behalf of the European Association for the Study of the Liver.
Original languageEnglish
Pages (from-to)552-557
JournalJournal of Hepatology
Volume40
Issue number3
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • Congenital portosystemic shunts
  • Hepatic encephalopathy
  • Magnetic resonance spectroscopy
  • Oral glutamine challenge

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