In this study we have evaluated the in vivo ability of triflusal (2- acetoxy-4-tri-fluoromethylbenzoic acid) to inhibit constitutive nuclear factor-kappa B (NF-κB) activation in the brain of postnatal rats. One week old Long-Evans black hooded rat pups received three oral administrations of triflusal (30 mg/kg) and were sacrificed at 9 days of age. After fixation, brains were cut in a cryostat and processed immunocytochemically for the demonstration of NF-κB. In control postnatal rats, NF-κB is constitutively present in some neuronal populations and in glial cells of white matter tracts. In contrast, triflusal treated rats showed a drastic downregulation of neuronal and glial NF-κB, both in the number of labelled cells and in the intensity of staining. The inhibition of NF-κB activation could be an important step in the modulation of inflammatory processes occurring after several pathological conditions. © 2000 Published by Elsevier Science Ireland Ltd.
|Publication status||Published - 7 Jul 2000|
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