Optopharmacological control of endogenous g protein-coupled receptors: An allosteric modulator to control endogenous g protein-coupled receptors with light

P. Gorostiza; C. Goudet; C. Zussy; S. Pittollo; X. Gomez-Santacana; K. Eckelt; X. Rovira; J. Dalton; J. -P. Pin; A. Llobet; J. Giraldo; A. Llebaria

Optopharmacological control of endogenous g protein-coupled receptors: An allosteric modulator to control endogenous g protein-coupled receptors with light

P. Gorostiza, C. Goudet, C. Zussy, S. Pittollo, X. Gomez-Santacana, K. Eckelt, X. Rovira, J. Dalton, J. -P. Pin, A. Llobet, J. Giraldo, A. Llebaria

Department of Paediatrics, Obstetrics and Gynaecology and Preventive Medicine and Public Health

Institut de Neurociències (INC_UAB)

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Controlling drug activity with light offers the possibility ofenhancing pharmacological selectivity with spatial and temporalregulation, thus enabling highly localized.Therapeutic effects and precise dosing patterns. We havedeveloped and characterized thefirst photoswitchable allostericmodulator of a G protein–coupled receptor. Alloswitch-1 is selectivefor the metabotropic glutamate receptor mGlu5 and enables theoptical control of endogenous mGlu receptors.

Original language	English
Journal	Journal of Neurochemistry
Volume	134
Issue number	S1
Publication status	Published - Aug 2015

Cite this

@article{11c1d58844cb411bb91b7c4af0864bec,

title = "Optopharmacological control of endogenous g protein-coupled receptors: An allosteric modulator to control endogenous g protein-coupled receptors with light",

abstract = "Controlling drug activity with light offers the possibility ofenhancing pharmacological selectivity with spatial and temporalregulation, thus enabling highly localized.Therapeutic effects and precise dosing patterns. We havedeveloped and characterized thefirst photoswitchable allostericmodulator of a G protein–coupled receptor. Alloswitch-1 is selectivefor the metabotropic glutamate receptor mGlu5 and enables theoptical control of endogenous mGlu receptors.",

author = "P. Gorostiza and C. Goudet and C. Zussy and S. Pittollo and X. Gomez-Santacana and K. Eckelt and X. Rovira and J. Dalton and Pin, {J. -P.} and A. Llobet and J. Giraldo and A. Llebaria",

year = "2015",

month = aug,

language = "English",

volume = "134",

number = "S1",

}

TY - JOUR

T1 - Optopharmacological control of endogenous g protein-coupled receptors

T2 - An allosteric modulator to control endogenous g protein-coupled receptors with light

AU - Gorostiza, P.

AU - Goudet, C.

AU - Zussy, C.

AU - Pittollo, S.

AU - Gomez-Santacana, X.

AU - Eckelt, K.

AU - Rovira, X.

AU - Dalton, J.

AU - Pin, J. -P.

AU - Llobet, A.

AU - Giraldo, J.

AU - Llebaria, A.

PY - 2015/8

Y1 - 2015/8

N2 - Controlling drug activity with light offers the possibility ofenhancing pharmacological selectivity with spatial and temporalregulation, thus enabling highly localized.Therapeutic effects and precise dosing patterns. We havedeveloped and characterized thefirst photoswitchable allostericmodulator of a G protein–coupled receptor. Alloswitch-1 is selectivefor the metabotropic glutamate receptor mGlu5 and enables theoptical control of endogenous mGlu receptors.

AB - Controlling drug activity with light offers the possibility ofenhancing pharmacological selectivity with spatial and temporalregulation, thus enabling highly localized.Therapeutic effects and precise dosing patterns. We havedeveloped and characterized thefirst photoswitchable allostericmodulator of a G protein–coupled receptor. Alloswitch-1 is selectivefor the metabotropic glutamate receptor mGlu5 and enables theoptical control of endogenous mGlu receptors.

UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360206300401&KeyUID=WOS:000360206300401

M3 - Article

VL - 134

IS - S1

ER -

Optopharmacological control of endogenous g protein-coupled receptors: An allosteric modulator to control endogenous g protein-coupled receptors with light

Abstract

Other files and links

Fingerprint

Cite this