Controlling drug activity with light offers the possibility ofenhancing pharmacological selectivity with spatial and temporalregulation, thus enabling highly localized.Therapeutic effects and precise dosing patterns. We havedeveloped and characterized thefirst photoswitchable allostericmodulator of a G protein–coupled receptor. Alloswitch-1 is selectivefor the metabotropic glutamate receptor mGlu5 and enables theoptical control of endogenous mGlu receptors.
|Journal||Journal of Neurochemistry|
|Publication status||Published - Aug 2015|