© 2017 American Physical Society. Optomechanical crystals, purposely designed and fabricated semiconductor nanostructures, are used to enhance the coupling between the electromagnetic field and the mechanical vibrations of matter at the nanoscale. However, in real optomechanical crystals, imperfections open extra channels where the transfer of energy is lost, reducing the optomechanical coupling efficiency. Here, we quantify the role of disorder in a paradigmatic one-dimensional optomechanical crystal with full phononic and photonic band gaps. We show how disorder can be exploited as a resource to enhance the optomechanical coupling beyond engineered structures, thus providing a new tool set for optomechanics.