Optimization of [11C]raclopride positron emission tomographic rat studies: Comparison of methods for image quantification

Èlia Torrent, Magí Farré, Ibane Abasolo, Olga Millan, Jordi Llop, Juan Domingo Gispert, Alba Ruiz, Deborah Pareto

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

The goal of this study was to compare different quantification approaches and reconstruction methods to estimate the binding potential in [ 11C]raclopride studies in rats. The final aim was to determine if the results obtained with short-acquisition scanning were comparable to the results obtained with long-acquistion (conventional) scanning. We analyzed two rat data sets: A baseline versus a pretreatment study (with cold raclopride) and a young versus an old animal group comparison. The study results support the contention that optimization of [11C]raclopride positron emission tomographic studies in rats by shortening the acquisition time is feasible. In addition, filtered backprojection is recommended as a reconstruction algorithm, although iterative methods may be more sensitive to detect within-group differences. © 2013 Decker Publishing.
Original languageEnglish
Pages (from-to)257-262
JournalMolecular Imaging
Volume12
Issue number4
DOIs
Publication statusPublished - 1 Jun 2013

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