Optimal Design of an Enzymatic Reactor for Flow Injection Analysis

M. Poch; J. L. Montesinos; M. Del Valle; J. Alonso; A. Araujo; J. L.F.C. Lima

doi:10.1021/bp00023a006

Optimal Design of an Enzymatic Reactor for Flow Injection Analysis

M. Poch, J. L. Montesinos, M. Del Valle, J. Alonso, A. Araujo, J. L.F.C. Lima

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

A simulation procedure for the optimization of enzymatic reactors used in sandwich flow injection systems is evaluated. The system is modeled as a plug‐flow reactor with axial dispersion. To calibrate it, dispersion coefficients can be evaluated using residence time distribution techniques; meanwhile, enzymatic kinetics must be determined for the system considered, according to the values of the substrate conversion attained. The model has been linked to an optimization routine based on the Powell algorithm. The proposed approach has been evaluated in a system performing simultaneous determinations of glucose and glycerol, considered the common carbon sources in a fermentation process. Copyright © 1993 American Institute of Chemical Engineers (AIChE)

Original language	English
Pages (from-to)	473-480
Journal	Biotechnology Progress
Volume	9
Issue number	5
DOIs	https://doi.org/10.1021/bp00023a006
Publication status	Published - 1 Feb 1993

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title = "Optimal Design of an Enzymatic Reactor for Flow Injection Analysis",

abstract = "A simulation procedure for the optimization of enzymatic reactors used in sandwich flow injection systems is evaluated. The system is modeled as a plug‐flow reactor with axial dispersion. To calibrate it, dispersion coefficients can be evaluated using residence time distribution techniques; meanwhile, enzymatic kinetics must be determined for the system considered, according to the values of the substrate conversion attained. The model has been linked to an optimization routine based on the Powell algorithm. The proposed approach has been evaluated in a system performing simultaneous determinations of glucose and glycerol, considered the common carbon sources in a fermentation process. Copyright {\textcopyright} 1993 American Institute of Chemical Engineers (AIChE)",

author = "M. Poch and Montesinos, {J. L.} and Valle, {M. Del} and J. Alonso and A. Araujo and Lima, {J. L.F.C.}",

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AU - Araujo, A.

AU - Lima, J. L.F.C.

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N2 - A simulation procedure for the optimization of enzymatic reactors used in sandwich flow injection systems is evaluated. The system is modeled as a plug‐flow reactor with axial dispersion. To calibrate it, dispersion coefficients can be evaluated using residence time distribution techniques; meanwhile, enzymatic kinetics must be determined for the system considered, according to the values of the substrate conversion attained. The model has been linked to an optimization routine based on the Powell algorithm. The proposed approach has been evaluated in a system performing simultaneous determinations of glucose and glycerol, considered the common carbon sources in a fermentation process. Copyright © 1993 American Institute of Chemical Engineers (AIChE)

AB - A simulation procedure for the optimization of enzymatic reactors used in sandwich flow injection systems is evaluated. The system is modeled as a plug‐flow reactor with axial dispersion. To calibrate it, dispersion coefficients can be evaluated using residence time distribution techniques; meanwhile, enzymatic kinetics must be determined for the system considered, according to the values of the substrate conversion attained. The model has been linked to an optimization routine based on the Powell algorithm. The proposed approach has been evaluated in a system performing simultaneous determinations of glucose and glycerol, considered the common carbon sources in a fermentation process. Copyright © 1993 American Institute of Chemical Engineers (AIChE)

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Optimal Design of an Enzymatic Reactor for Flow Injection Analysis

Abstract

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