Opposite cannabis-cognition associations in psychotic patients depending on family history

Ana González-Pinto, Itxaso González-Ortega, Susana Alberich, Sonia Ruiz De Azúa, Miguel Bernardo, Miquel Bioque, Bibiana Cabrera, Iluminada Corripio, Celso Arango, Antonio Lobo, Ana M. Sánchez-Torres, Manuel J. Cuesta, Amaia Ugarte, Miryam Fernández, Gisela Mezquida, Ana Meseguer, Eduard Vieta, Carla Torrent, Fernando Contreras, Auria AlbaceteAnna Alonso-Solís, Mireia Rabella, Lucía Moreno-Izco, Judith Usall, Anna Butjosa, Ángela Ibáñez, Julio Bobes, Susana Al-Halabí, Ma Teresa Zapata-Usábel, Isabel Laporta-Herrero, Vicent Balanzá-Martínez, Daniel Bergé, Anna Mané, Roberto Rodriguez-Jimenez, Isabel Morales-Muñoz, Miguel Gutierrez, Arantzazu Zabala, Salvador Sarró, Ramón Landin-Romero, Elena De La Serna, Inmaculada Baeza, Mara Parellada, Ana Espliego, Julio San Juan, Eduardo Aguilar

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    16 Citations (Scopus)


    © 2016 González-Pinto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis.
    Original languageEnglish
    Article numbere0160949
    JournalPloS one
    Issue number8
    Publication statusPublished - 1 Aug 2016


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