Ontogeny of the Major Xenobiotic-Metabolizing Enzymes Expression and the Dietary Lipids Modulatory Effect in the Rat Dimethylbenz(a)anthracene-Induced Breast Cancer Model

Miguel Ángel Manzanares; Montserrat Solanas; Raquel Moral; Raquel Escrich; Elena Vela; Eduard Escrich

doi:https://doi.org/10.1002/jbt.21596

Ontogeny of the Major Xenobiotic-Metabolizing Enzymes Expression and the Dietary Lipids Modulatory Effect in the Rat Dimethylbenz(a)anthracene-Induced Breast Cancer Model

Miguel Ángel Manzanares, Montserrat Solanas, Raquel Moral, Raquel Escrich, Elena Vela, Eduard Escrich

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

© 2014 Wiley Periodicals, Inc. Breast cancer is the most common malignancy in women worldwide. Environmental factors such as xenobiotic exposure and lifestyle and nutrition play a key role in its etiology. This study was designed to evaluate the age-related changes in the expression of major xenobiotic-metabolizing enzymes (XMEs) in the rat liver and the mammary gland in the dimethylbenz(a)anthracene-induced breast cancer model. The influence of dietary lipids on the ontogeny of XMEs was also evaluated. mRNA and protein levels of phase I (CYP1A1, CYP1A2, and CYP1B1) and phase II (NAD(P)H:quinone acceptor oxidoreductase 1 and GSTP1) enzymes were analyzed, as well as their regulation by AhR and Nrf2, respectively. Results showed differences in the phase I enzymes expression, whereas little changes were obtained in phase II. High corn oil and olive oil diets differentially influenced the expression of age-related changes, suggesting that the different susceptibility to xenobiotic exposure depending upon the age may be modulated by dietary factors.

Original language	English
Pages (from-to)	539-548
Journal	Journal of Biochemical and Molecular Toxicology
Volume	28
DOIs	https://doi.org/10.1002/jbt.21596
Publication status	Published - 1 Dec 2014

Keywords

Breast Cancer Model
Dietary Lipids
Ontogeny
Polycyclic Aromatic Hydrocarbons (PAHs)
Xenobiotic-Metabolizing Enzymes (XMEs)

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Manzanares, Miguel Ángel ; Solanas, Montserrat ; Moral, Raquel ; Escrich, Raquel ; Vela, Elena ; Escrich, Eduard. / Ontogeny of the Major Xenobiotic-Metabolizing Enzymes Expression and the Dietary Lipids Modulatory Effect in the Rat Dimethylbenz(a)anthracene-Induced Breast Cancer Model. In: Journal of Biochemical and Molecular Toxicology. 2014 ; Vol. 28. pp. 539-548.

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abstract = "{\textcopyright} 2014 Wiley Periodicals, Inc. Breast cancer is the most common malignancy in women worldwide. Environmental factors such as xenobiotic exposure and lifestyle and nutrition play a key role in its etiology. This study was designed to evaluate the age-related changes in the expression of major xenobiotic-metabolizing enzymes (XMEs) in the rat liver and the mammary gland in the dimethylbenz(a)anthracene-induced breast cancer model. The influence of dietary lipids on the ontogeny of XMEs was also evaluated. mRNA and protein levels of phase I (CYP1A1, CYP1A2, and CYP1B1) and phase II (NAD(P)H:quinone acceptor oxidoreductase 1 and GSTP1) enzymes were analyzed, as well as their regulation by AhR and Nrf2, respectively. Results showed differences in the phase I enzymes expression, whereas little changes were obtained in phase II. High corn oil and olive oil diets differentially influenced the expression of age-related changes, suggesting that the different susceptibility to xenobiotic exposure depending upon the age may be modulated by dietary factors.",

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Ontogeny of the Major Xenobiotic-Metabolizing Enzymes Expression and the Dietary Lipids Modulatory Effect in the Rat Dimethylbenz(a)anthracene-Induced Breast Cancer Model. / Manzanares, Miguel Ángel; Solanas, Montserrat ; Moral, Raquel; Escrich, Raquel; Vela, Elena; Escrich, Eduard.

In: Journal of Biochemical and Molecular Toxicology, Vol. 28, 01.12.2014, p. 539-548.

Research output: Contribution to journal › Article › Research › peer-review

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