One step preparation and 1,3-dipolar cycloadditions of (S)-5-hydroxymethyl-1-pyrroline N-oxide

Montserrat Closa, Pedro De March, Marta Figueredo, Josep Font

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)


The cyclic nitrone 1b has been prepared in enantiomerically pure form by direct oxidation of L-(+)-prolinol with dimethyldioxirane. A complete diastereoface differentiation has been observed in the 1,3-dipolar cycloaddition reaction of this nitrone to several 1,2-disubstituted electron deficient olefins.
Original languageEnglish
Pages (from-to)1031-1037
JournalTetrahedron Asymmetry
Issue number7
Publication statusPublished - 11 Apr 1997


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