One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model

M. Fort, M. Sibila, E. Pérez-Martín, M. Nofrarías, E. Mateu, J. Segalés

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125 Citations (Scopus)

Abstract

The immunogenicity and efficacy generated by one dose of a PCV2 sub-unit vaccine (Porcilis PCV®) were evaluated in 3-week-old conventional piglets. Vaccination induced both humoral and cell-mediated responses against PCV2, which were increased after the challenge with a PCV2 genotype "b" isolate. High levels of maternally derived antibodies (IPMA ≥ 10 log2) at the time of vaccination were found to interfere with the active seroconversion, whereas titres below 8 log2 allowed the development of a proper antibody response. Nevertheless, the immunity induced by one dose of the product was partly protective against PCV2 infection, since viremia, shedding and viral load in tissues were significantly reduced in vaccinated pigs compared to controls. © 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)4031-4037
JournalVaccine
Volume27
DOIs
Publication statusPublished - 19 Jun 2009

Keywords

  • Cell-mediated immunity
  • IFN-γ
  • Porcine circovirus type 2 (PCV2)
  • Postweaning multisystemic wasting syndrome (PMWS)
  • Vaccine

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