Oncosuppressive functions of tribbles pseudokinase 3

María Salazar, Mar Lorente, Alba Orea-Soufi, David Dávila, Tatiana Erazo, José Lizcano, Arkaitz Carracedo, Endre Kiss-Toth, Guillermo Velasco

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

© 2015 Authors; published by Portland Press Limited. Tribbles pseudokinase 3 (TRIB3) belongs to the tribbles family of pseudokinases. In this article, we summarize several observation obtained by our laboratories supporting that TRIB3 plays a crucial role in the anti-cancer activity of cannabinoids (a novel family of potential anti-cancer agents derived from marijuana) and that TRIB3 genetic inactivation enhances cancer generation and progression.
Original languageEnglish
Pages (from-to)1122-1126
JournalBiochemical Society Transactions
Volume43
Issue number5
DOIs
Publication statusPublished - 1 Oct 2015

Keywords

  • Animal models of cancer
  • Autophagy
  • Cannabinoids
  • Endoplasmic reticulum (ER) stress
  • Tribbles pseudokinases

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