On the stereoselective hydrogenation of chiral cyclobutyl dehydro-amino acid derivatives: Influence of the catalyst in the π-facial diastereoselection

Gemma P. Aguado, Angel Alvarez-Larena, Ona Illa, Albertina G. Moglioni, Rosa M. Ortuo

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Several optically active cyclobutyl dehydro-amino acid derivatives have been hydrogenated employing Wilkinson, (S,S)-chiraphos-Rh and Et-duphos-Rh (both enantiomers) as catalysts. The use of a chiral catalyst has been revealed to be crucial for the production of saturated amino acids with high stereoselectivity from substrates in which the chiral cyclobutyl unit is separated from the double bond by a methylene group. © 2001 Elsevier Science Ltd.
Original languageEnglish
Pages (from-to)25-28
JournalTetrahedron Asymmetry
Volume12
Issue number1
DOIs
Publication statusPublished - 5 Feb 2001

Fingerprint Dive into the research topics of 'On the stereoselective hydrogenation of chiral cyclobutyl dehydro-amino acid derivatives: Influence of the catalyst in the π-facial diastereoselection'. Together they form a unique fingerprint.

Cite this