On the interference of J(HH) modulation in HSQMBC-IPAP and HMBC-IPAP experiments

Josep Saurí; Teodor Parella

doi:10.1002/mrc.3977

On the interference of J(HH) modulation in HSQMBC-IPAP and HMBC-IPAP experiments

Josep Saurí, Teodor Parella

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Abstract

The effects of phase modulation due to homonuclear proton-proton coupling constants in HSQMBC-IPAP and HMBC-IPAP experiments are experimentally evaluated. We show that accurate values of small proton-carbon coupling constants, nJCH, can be extracted even for phase-distorted cross-peaks obtained from a selHSQMBC experiment applied simultaneously on two mutually J-coupled protons. On the other hand, an assessment of the reliability of nJCH measurement from distorted cross-peaks obtained in broadband IPAP versions of equivalent HMBC and HSQMBC experiments is also presented. Finally, we show that HMBC-COSY experiments could be an excellent complement to HMBC for the measurement of small nJCH values. Copyright © 2013 John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	509-516
Journal	Magnetic Resonance in Chemistry
Volume	51
Issue number	9
DOIs	https://doi.org/10.1002/mrc.3977
Publication status	Published - 1 Sep 2013

Keywords

HMBC
HSQMBC
IPAP
proton-carbon coupling constants
selHSQMBC

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title = "On the interference of J(HH) modulation in HSQMBC-IPAP and HMBC-IPAP experiments",

abstract = "The effects of phase modulation due to homonuclear proton-proton coupling constants in HSQMBC-IPAP and HMBC-IPAP experiments are experimentally evaluated. We show that accurate values of small proton-carbon coupling constants, nJCH, can be extracted even for phase-distorted cross-peaks obtained from a selHSQMBC experiment applied simultaneously on two mutually J-coupled protons. On the other hand, an assessment of the reliability of nJCH measurement from distorted cross-peaks obtained in broadband IPAP versions of equivalent HMBC and HSQMBC experiments is also presented. Finally, we show that HMBC-COSY experiments could be an excellent complement to HMBC for the measurement of small nJCH values. Copyright {\textcopyright} 2013 John Wiley & Sons, Ltd.",

keywords = "HMBC, HSQMBC, IPAP, proton-carbon coupling constants, selHSQMBC",

author = "Josep Saur{\'i} and Teodor Parella",

year = "2013",

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doi = "10.1002/mrc.3977",

language = "English",

volume = "51",

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TY - JOUR

T1 - On the interference of J(HH) modulation in HSQMBC-IPAP and HMBC-IPAP experiments

AU - Saurí, Josep

AU - Parella, Teodor

PY - 2013/9/1

Y1 - 2013/9/1

N2 - The effects of phase modulation due to homonuclear proton-proton coupling constants in HSQMBC-IPAP and HMBC-IPAP experiments are experimentally evaluated. We show that accurate values of small proton-carbon coupling constants, nJCH, can be extracted even for phase-distorted cross-peaks obtained from a selHSQMBC experiment applied simultaneously on two mutually J-coupled protons. On the other hand, an assessment of the reliability of nJCH measurement from distorted cross-peaks obtained in broadband IPAP versions of equivalent HMBC and HSQMBC experiments is also presented. Finally, we show that HMBC-COSY experiments could be an excellent complement to HMBC for the measurement of small nJCH values. Copyright © 2013 John Wiley & Sons, Ltd.

AB - The effects of phase modulation due to homonuclear proton-proton coupling constants in HSQMBC-IPAP and HMBC-IPAP experiments are experimentally evaluated. We show that accurate values of small proton-carbon coupling constants, nJCH, can be extracted even for phase-distorted cross-peaks obtained from a selHSQMBC experiment applied simultaneously on two mutually J-coupled protons. On the other hand, an assessment of the reliability of nJCH measurement from distorted cross-peaks obtained in broadband IPAP versions of equivalent HMBC and HSQMBC experiments is also presented. Finally, we show that HMBC-COSY experiments could be an excellent complement to HMBC for the measurement of small nJCH values. Copyright © 2013 John Wiley & Sons, Ltd.

KW - HMBC

KW - HSQMBC

KW - IPAP

KW - proton-carbon coupling constants

KW - selHSQMBC

U2 - 10.1002/mrc.3977

DO - 10.1002/mrc.3977

M3 - Article

VL - 51

SP - 509

EP - 516

IS - 9

ER -