Abstract
The effects of phase modulation due to homonuclear proton-proton coupling constants in HSQMBC-IPAP and HMBC-IPAP experiments are experimentally evaluated. We show that accurate values of small proton-carbon coupling constants, nJCH, can be extracted even for phase-distorted cross-peaks obtained from a selHSQMBC experiment applied simultaneously on two mutually J-coupled protons. On the other hand, an assessment of the reliability of nJCH measurement from distorted cross-peaks obtained in broadband IPAP versions of equivalent HMBC and HSQMBC experiments is also presented. Finally, we show that HMBC-COSY experiments could be an excellent complement to HMBC for the measurement of small nJCH values. Copyright © 2013 John Wiley & Sons, Ltd.
Original language | English |
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Pages (from-to) | 509-516 |
Journal | Magnetic Resonance in Chemistry |
Volume | 51 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Sep 2013 |
Keywords
- HMBC
- HSQMBC
- IPAP
- proton-carbon coupling constants
- selHSQMBC