Copyright © 2019 Edith Annette Cabrera-Hernández et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Dynamic directional modulation (DDM) has already proven to be an efficient technique to achieve physical layer security in wireless communications. System architectures based on vector modulators provide a flexible framework to implement synthesis methods that allow us to obtain increased security and/or independent multichannel transmissions. However, the implementation of DDM with vector modulators requires an accurate calibration (amplitude and phase) of every component in the RF path. In this contribution, we study the sensitivity of the response of a DDM system based on commercial vector modulators showing how to correct the nonideal behavior of all the components thanks to the flexibility provided by the vector modulator.