Oligodendroglial Gliomatosis cerebri in a Poodle

A. Galán, S. Guil-Luna, Y. Millán, E. M. Martín-Suárez, M. Pumarola, J. M. de las Mulas*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Gliomatosis cerebri (GC) is a rare, diffusely infiltrating, glial cell tumour of neuroepithelial origin. This report describes a case of oligodendroglial GC in a 6-year-old male Poodle with central nervous system symptoms. Computed tomography revealed anomalous parenchyma density and ventricular asymmetry. Cerebrospinal fluid showed elevated protein (30 mg dL-1) and nucleated cell count (20 μL-1). Presumptive diagnosis of necrotizing meningoencephalitis was made. Because of rapid deterioration of the general condition of the animal, the dog was euthanized. Histologically there was an infiltration of round or ovoid neoplastic cells in the white matter of the left cerebral hemisphere and in leptomeninges. Immunohistochemistry showed that 80% of the neoplastic cells expressed Olig2 and some 50% expressed glial fibrilary acidic protein. On the basis of clinical, histological and immunohistochemical features, a diagnosis of oligodendoglial GC was done. This case represents the first report of a case of oligodendroglial GC in the canid.

Original languageAmerican English
Pages (from-to)254-262
Number of pages9
JournalVeterinary and Comparative Oncology
Volume8
Issue number4
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Dog
  • Gliomatosis cerebri
  • Olig2
  • Oligodendroglial tumour
  • Tumor

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