SCIATIC nerve resection leaving a 15 mm gap could not be repaired by bridging the stumps with a silicone tube prefilled with a laminin gel. However, when purified olfactory ensheathing cells (EC) were added to the gel filling the tube, successful axonal regeneration was observed in 50% of rats. With 12 mm gaps, regeneration occurred in 79% of rats with transplanted EC compared with 60% of those receiving collagen gel alone. Therefore, ECs help repair severe peripheral nerve injuries, in addition to their ability to promote axonal regeneration within the central nervous system.
- Ensheathing glia
- Nerve regeneration
- Sciatic nerve
- Tubular prostheses
Verdú, E., Navarro, X., Gudiño-Cabrera, G., Rodríguez, F. J., Ceballos, D., Valero, A., & Nieto-Sampedro, M. (1999). Olfactory bulb ensheathing cells enhance peripheral nerve regeneration. NeuroReport, 10(5), 1097-1101. https://doi.org/10.1097/00001756-199904060-00035