Olfactory bulb ensheathing cells enhance peripheral nerve regeneration

Enrique Verdú, Xavier Navarro, Graciela Gudiño-Cabrera, Francisco J. Rodríguez, Dolores Ceballos, Antoni Valero, Manuel Nieto-Sampedro

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)

Abstract

SCIATIC nerve resection leaving a 15 mm gap could not be repaired by bridging the stumps with a silicone tube prefilled with a laminin gel. However, when purified olfactory ensheathing cells (EC) were added to the gel filling the tube, successful axonal regeneration was observed in 50% of rats. With 12 mm gaps, regeneration occurred in 79% of rats with transplanted EC compared with 60% of those receiving collagen gel alone. Therefore, ECs help repair severe peripheral nerve injuries, in addition to their ability to promote axonal regeneration within the central nervous system.
Original languageEnglish
Pages (from-to)1097-1101
JournalNeuroReport
Volume10
Issue number5
DOIs
Publication statusPublished - 6 Apr 1999

Keywords

  • Ensheathing glia
  • Nerve regeneration
  • Sciatic nerve
  • Tubular prostheses

Fingerprint Dive into the research topics of 'Olfactory bulb ensheathing cells enhance peripheral nerve regeneration'. Together they form a unique fingerprint.

  • Cite this

    Verdú, E., Navarro, X., Gudiño-Cabrera, G., Rodríguez, F. J., Ceballos, D., Valero, A., & Nieto-Sampedro, M. (1999). Olfactory bulb ensheathing cells enhance peripheral nerve regeneration. NeuroReport, 10(5), 1097-1101. https://doi.org/10.1097/00001756-199904060-00035