Occurrence of multiple ribonucleotide reductase classes in γ-Proteobacteria species

Eduard Torrents, Albert Jordan, Margareta Karlsson, Isidre Gibert

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Ribonucleotide reductase (RNR) is central to de novo synthesis of deoxyribonucleotides and essential for all living cells. Three classes have been described; class I is oxygen dependent and represented by two subclasses, Ia (NrdAB) and Ib (NrdEF); class II (NrdJ) is indifferent to oxygen; and class III (NrdDG) is oxygen sensitive. More than one class can be found in an organism, reflecting the oxygen status of its environment. We have investigated, by using PCR and Southern blot, the occurrence of the different classes among species of the γ-Proteobacteria. Class III are present in all species tested, but the presence of the other classes varies. Some species contain one unique additional enzyme, class Ia, Ib, or II, whereas others contain two additional enzymes, class Ia and Ib, or class Ia and II.
Original languageEnglish
Pages (from-to)346-351
JournalCurrent Microbiology
Volume41
DOIs
Publication statusPublished - 1 Jan 2000

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