Obesity-related metabolic disorders in childhood and adolescence

D. Yeste, A. Carrascosa

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Abstract

Obesity is the most frequent nutritional disorder in childhood and adolescence. The rise in its prevalence and severity has underlined the numerous and significant obesity-related metabolic disorders. Altered glucose metabolism, manifested as impaired glucose tolerance, appears early in severely obese children and adolescents. Obese young people with glucose intolerance are characterized by marked peripheral insulin resistance and relative beta-cell failure. Lipid deposition in muscle and the visceral compartment, and not only obesity per se, is related to increased peripheral insulin resistance, the triggering factor of the metabolic syndrome. Other elements of the metabolic syndrome, such as dyslipidaemia, and hypertension, are already present in obese youngsters and worsen with the degree of obesity. The long-term impact of obesity-related insulin resistance on cardiovascular morbidity in these patients is expected to emerge as these youngsters become young adults. © 2011 Asociación Española de Pediatría. Published by Elsevier España, S.L. All rights reserved.
Original languageEnglish
JournalAnales de Pediatria
Volume75
Issue number2
DOIs
Publication statusPublished - 1 Aug 2011

Keywords

  • Childhood and adolescence
  • Impaired glucose tolerance
  • Insulin resistance
  • Metabolic syndrome
  • Obesity
  • Type 2 diabetes

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