Nuclear reprogramming of cancer stem cells: Corrupting the epigenetic code of cell identity with oncometabolites

Javier A. Menendez, Tomás Alarcón

    Research output: Contribution to journalArticleResearchpeer-review

    2 Citations (Scopus)

    Abstract

    © 2016, © 2016 Taylor & Francis Group, LLC. Generation of cancer stem cell (CSC)-like cells might occur through metabolic corruption of the epigenetic codes that govern cell identity. We recently identified how archetypal oncometabolites, without altering the baseline expression of endogenous stem cell maintenance genes but endowing cells with epigenetic states refractory to differentiation, considerably enhance the global kinetic efficiency of nuclear reprogramming processes that generate CSC-like states de novo. This study highlights that metabolo-epigenetic axes of communication can direct the development and maintenance of CSCs during the natural history of cancer diseases.
    Original languageEnglish
    Article numbere1160854
    JournalMolecular and Cellular Oncology
    Volume3
    Issue number6
    DOIs
    Publication statusPublished - 1 Nov 2016

    Keywords

    • Cancer stem cells
    • epigenetics
    • nuclear reprogramming
    • oncometabolites

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