Nuclear reprogramming of cancer stem cells: Corrupting the epigenetic code of cell identity with oncometabolites

Javier A. Menendez; Tomás Alarcón

doi:10.1080/23723556.2016.1160854

Nuclear reprogramming of cancer stem cells: Corrupting the epigenetic code of cell identity with oncometabolites

Javier A. Menendez, Tomás Alarcón

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

© 2016, © 2016 Taylor & Francis Group, LLC. Generation of cancer stem cell (CSC)-like cells might occur through metabolic corruption of the epigenetic codes that govern cell identity. We recently identified how archetypal oncometabolites, without altering the baseline expression of endogenous stem cell maintenance genes but endowing cells with epigenetic states refractory to differentiation, considerably enhance the global kinetic efficiency of nuclear reprogramming processes that generate CSC-like states de novo. This study highlights that metabolo-epigenetic axes of communication can direct the development and maintenance of CSCs during the natural history of cancer diseases.

Original language	English
Article number	e1160854
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	6
DOIs	https://doi.org/10.1080/23723556.2016.1160854
Publication status	Published - 1 Nov 2016

Keywords

Cancer stem cells
epigenetics
nuclear reprogramming
oncometabolites

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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title = "Nuclear reprogramming of cancer stem cells: Corrupting the epigenetic code of cell identity with oncometabolites",

abstract = "{\textcopyright} 2016, {\textcopyright} 2016 Taylor & Francis Group, LLC. Generation of cancer stem cell (CSC)-like cells might occur through metabolic corruption of the epigenetic codes that govern cell identity. We recently identified how archetypal oncometabolites, without altering the baseline expression of endogenous stem cell maintenance genes but endowing cells with epigenetic states refractory to differentiation, considerably enhance the global kinetic efficiency of nuclear reprogramming processes that generate CSC-like states de novo. This study highlights that metabolo-epigenetic axes of communication can direct the development and maintenance of CSCs during the natural history of cancer diseases.",

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AU - Alarcón, Tomás

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AB - © 2016, © 2016 Taylor & Francis Group, LLC. Generation of cancer stem cell (CSC)-like cells might occur through metabolic corruption of the epigenetic codes that govern cell identity. We recently identified how archetypal oncometabolites, without altering the baseline expression of endogenous stem cell maintenance genes but endowing cells with epigenetic states refractory to differentiation, considerably enhance the global kinetic efficiency of nuclear reprogramming processes that generate CSC-like states de novo. This study highlights that metabolo-epigenetic axes of communication can direct the development and maintenance of CSCs during the natural history of cancer diseases.

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KW - epigenetics

KW - nuclear reprogramming

KW - oncometabolites

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