NT-proBNP: A cardiac biomarker to assess prognosis in non-Hodgkin lymphoma

Eva Gimeno, Miquel Gómez, Juan Ramón González, Josep Comín, Alberto Alvarez-Larrán, Blanca Sánchez-González, Lluis Molina, Eva Domingo-Domenech, Francesc Garcia-Pallarols, Carmen Pedro, Eugenia Abella, Carles Vilaplana, Silvia de Sanjosé, Carlos Besses, Antonio Salar

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    NT-proBNP provides diagnostic and prognostic information in heart syndromes but its role in cancer has not yet been established. The prognostic value of NT-proBNP was prospectively studied in 104 non-Hodgkin lymphoma (NHL) patients treated with chemotherapy. Echocardiography and NT-proBNP were determined prior to treatment. In multivariate analysis, NT-proBNP ≥ 900. pg/ml was the variable with higher risk of death (adjusted hazard ratio 11.1; 95% CI 3.8-32.9; P< 0.001). The C statistic for NT-proBNP ≥ 900 pg/ml was significantly better than IPI score for prediction of survival. These findings suggest that NT-proBNP ≥ 900. pg/ml could be considered a useful marker for risk assessment in NHL patients treated with chemotherapy. © 2011 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)715-720
    JournalLeukemia Research
    Issue number6
    Publication statusPublished - 1 Jun 2011


    • Non-Hodgkin lymphoma
    • NT-proBNP
    • Prognostic factor

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    Gimeno, E., Gómez, M., González, J. R., Comín, J., Alvarez-Larrán, A., Sánchez-González, B., Molina, L., Domingo-Domenech, E., Garcia-Pallarols, F., Pedro, C., Abella, E., Vilaplana, C., de Sanjosé, S., Besses, C., & Salar, A. (2011). NT-proBNP: A cardiac biomarker to assess prognosis in non-Hodgkin lymphoma. Leukemia Research, 35(6), 715-720. https://doi.org/10.1016/j.leukres.2011.01.018