Novobiocin inhibits the antimicrobial resistance acquired through DNA damage-induced mutagenesis in Acinetobacter baumannii

Luis M. Jara, María Pérez-Varela, Jordi Corral, Marta Arch, Pilar Cortés, Germán Bou, Jesús Aranda, Jordi Barbé

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Copyright © 2015, American Society for Microbiology. All Rights Reserved. Acinetobacter baumannii, a worldwide emerging nosocomial pathogen, acquires antimicrobial resistances in response to DNA-damaging agents, which increase the expression of multiple error-prone DNA polymerase components. Here we show that the aminocoumarin novobiocin, which inhibits the DNA damage response in Gram-positive bacteria, also inhibits the expression of error-prone DNA polymerases in this Gram-negative multidrug-resistant pathogen and, consequently, its potential acquisition of antimicrobial resistance through DNA damage-induced mutagenesis.
Original languageEnglish
Pages (from-to)637-639
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016

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