Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

Derek J. Hausenloy, David Garcia-Dorado, Hans Erik Bøtker, Sean M. Davidson, James Downey, Felix B. Engel, Robert Jennings, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Michel Ovize, Cinzia Perrino, Fabrice Prunier, Rainer Schulz, Joost P.G. Sluijter, Linda W. Van Laake, Jakob Vinten-Johansen, Derek M. Yellon, Kirsti Ytrehus, Gerd HeuschPéter Ferdinandy

Research output: Contribution to journalReview articleResearchpeer-review

168 Citations (Scopus)

Abstract

© 2017 The Author. Ischaemic heart disease and the heart failure that often results, remain the leading causes of death and disability in Europe and worldwide. As such, in order to prevent heart failure and improve clinical outcomes in patients presenting with an acute ST-segment elevation myocardial infarction and patients undergoing coronary artery bypass graft surgery, novel therapies are required to protect the heart against the detrimental effects of acute ischaemia/reperfusion injury (IRI). During the last three decades, a wide variety of ischaemic conditioning strategies and pharmacological treatments have been tested in the clinic - however, their translation from experimental to clinical studies for improving patient outcomes has been both challenging and disappointing. Therefore, in this Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart, we critically analyse the current state of ischaemic conditioning in both the experimental and clinical settings, provide recommendations for improving its translation into the clinical setting, and highlight novel therapeutic targets and new treatment strategies for reducing acute myocardial IRI.
Original languageEnglish
Pages (from-to)564-585
JournalCardiovascular Research
Volume113
Issue number6
DOIs
Publication statusPublished - 1 May 2017

Keywords

  • Cardioprotection
  • Ischaemia
  • Ischaemic conditioning
  • Myocardial Infarction
  • Reperfusion

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