Novel selective 1D experiments based on heteronuclear J cross-polarization

Selective 1H-13C inverse NMR experiments based on heteronuclear cross-polarization (HCP) are presented. Practical details on the implementation of one-bond [1J(C,H)] optimized and pseudo-3D HCP experiments combined with gradient coherence selection are reported. On the other hand, accurate values for long-range proton-carbon coupling constants [nJ(C,H); n > 1] can be measured from ultra-clean in-phase 1D proton multiplets resulting of long-range optimized experiments. Alternatively, such heteronuclear connectivities can be also clearly elucidated using a 1H-selective 13C-detected version in which signals exclusively arise from selective transfer of a selected proton to all long-range coupled carbon nuclei. Copyright © 1999 John Wiley & Sons, Ltd.