Novel insights in SHBG regulation and clinical implications

Rafael Simó, Cristina Sáez-López, Anna Barbosa-Desongles, Cristina Hernández, David M. Selva

Research output: Contribution to journalReview articleResearchpeer-review

181 Citations (Scopus)


© 2015 Elsevier Ltd. Sex hormone-binding globulin (SHBG) is produced and secreted by the liver into the bloodstream where it binds sex steroids and regulates their bioavailability. Traditionally, body mass index (BMI) was thought to be the major determinant of SHBG concentrations and hyperinsulinemia the main cause for low SHBG levels found in obesity. However, no mechanisms have ever been described. Emerging evidence now shows that liver fat content rather than BMI is a strong determinant of circulating SHBG. In this review we discuss evidence demonstrating that insulin might not regulate SHBG production, describe putative molecular mechanisms by which proinflammatory cytokines downregulate SHBG, and comment on recent findings suggesting dietary SHBG regulation. Finally, clinical implications of all of these findings and future perspectives are discussed.
Original languageEnglish
Pages (from-to)376-383
JournalTrends in Endocrinology and Metabolism
Issue number7
Publication statusPublished - 1 Jul 2015


  • Cytokines
  • Insulin
  • Sex hormone-binding globulin


Dive into the research topics of 'Novel insights in SHBG regulation and clinical implications'. Together they form a unique fingerprint.

Cite this