Novel human metapneumovirus with a 180-nucleotide duplication in the G gene

María Piñana; Jorgina Vila; Laura Gimferrer; María Valls; Cristina Andrés; María Gema Codina; Javier Ramón; María Carmen Martín; Francisco Fuentes; Rosario Saiz; Pilar Alcubilla; Carlos Rodrigo; Tomàs Pumarola; Andrés Antón

doi:10.2217/fmb-2016-0211

Novel human metapneumovirus with a 180-nucleotide duplication in the G gene

María Piñana, Jorgina Vila, Laura Gimferrer, María Valls, Cristina Andrés, María Gema Codina, Javier Ramón, María Carmen Martín, Francisco Fuentes, Rosario Saiz, Pilar Alcubilla, Carlos Rodrigo, Tomàs Pumarola, Andrés Antón

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Abstract

© 2017 Future Medicine Ltd. Aim: To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016. Materials & methods: Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis. Results: A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received. The highest circulation was from February to April, with a prevalence of 3%. Different genetic groups within both genotypes were detected at variable levels. A 180-nucleotide duplication was first characterized within the G gene in nine cases, mostly related to lower respiratory-tract infection. Conclusion: This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features.

Original language	English
Pages (from-to)	565-571
Journal	Future Microbiology
Volume	12
Issue number	7
DOIs	https://doi.org/10.2217/fmb-2016-0211
Publication status	Published - 1 Jun 2017

Keywords

G protein
duplication
evolution
genetic diversity
genotype
human metapneumovirus
molecular epidemiology
respiratory tract infection
respiratory virus
surveillance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fmb-2016-0211

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title = "Novel human metapneumovirus with a 180-nucleotide duplication in the G gene",

abstract = "{\textcopyright} 2017 Future Medicine Ltd. Aim: To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016. Materials & methods: Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis. Results: A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received. The highest circulation was from February to April, with a prevalence of 3%. Different genetic groups within both genotypes were detected at variable levels. A 180-nucleotide duplication was first characterized within the G gene in nine cases, mostly related to lower respiratory-tract infection. Conclusion: This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features.",

keywords = "G protein, duplication, evolution, genetic diversity, genotype, human metapneumovirus, molecular epidemiology, respiratory tract infection, respiratory virus, surveillance",

author = "Mar{\'i}a Pi{\~n}ana and Jorgina Vila and Laura Gimferrer and Mar{\'i}a Valls and Cristina Andr{\'e}s and Codina, {Mar{\'i}a Gema} and Javier Ram{\'o}n and Mart{\'i}n, {Mar{\'i}a Carmen} and Francisco Fuentes and Rosario Saiz and Pilar Alcubilla and Carlos Rodrigo and Tom{\`a}s Pumarola and Andr{\'e}s Ant{\'o}n",

year = "2017",

month = jun,

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doi = "10.2217/fmb-2016-0211",

language = "English",

volume = "12",

pages = "565--571",

journal = "Future Microbiology",

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T1 - Novel human metapneumovirus with a 180-nucleotide duplication in the G gene

AU - Piñana, María

AU - Vila, Jorgina

AU - Gimferrer, Laura

AU - Valls, María

AU - Andrés, Cristina

AU - Codina, María Gema

AU - Ramón, Javier

AU - Martín, María Carmen

AU - Fuentes, Francisco

AU - Saiz, Rosario

AU - Alcubilla, Pilar

AU - Rodrigo, Carlos

AU - Pumarola, Tomàs

AU - Antón, Andrés

PY - 2017/6/1

Y1 - 2017/6/1

N2 - © 2017 Future Medicine Ltd. Aim: To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016. Materials & methods: Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis. Results: A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received. The highest circulation was from February to April, with a prevalence of 3%. Different genetic groups within both genotypes were detected at variable levels. A 180-nucleotide duplication was first characterized within the G gene in nine cases, mostly related to lower respiratory-tract infection. Conclusion: This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features.

AB - © 2017 Future Medicine Ltd. Aim: To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016. Materials & methods: Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis. Results: A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received. The highest circulation was from February to April, with a prevalence of 3%. Different genetic groups within both genotypes were detected at variable levels. A 180-nucleotide duplication was first characterized within the G gene in nine cases, mostly related to lower respiratory-tract infection. Conclusion: This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features.

KW - G protein

KW - duplication

KW - evolution

KW - genetic diversity

KW - genotype

KW - human metapneumovirus

KW - molecular epidemiology

KW - respiratory tract infection

KW - respiratory virus

KW - surveillance

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DO - 10.2217/fmb-2016-0211

M3 - Article

SN - 1746-0913

VL - 12

SP - 565

EP - 571

JO - Future Microbiology

JF - Future Microbiology

IS - 7

ER -

Novel human metapneumovirus with a 180-nucleotide duplication in the G gene

Abstract

Keywords

UN SDGs

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