Novel human metapneumovirus with a 180-nucleotide duplication in the G gene

María Piñana, Jorgina Vila, Laura Gimferrer, María Valls, Cristina Andrés, María Gema Codina, Javier Ramón, María Carmen Martín, Francisco Fuentes, Rosario Saiz, Pilar Alcubilla, Carlos Rodrigo, Tomàs Pumarola, Andrés Antón

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11 Citations (Scopus)

Abstract

© 2017 Future Medicine Ltd. Aim: To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016. Materials & methods: Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis. Results: A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received. The highest circulation was from February to April, with a prevalence of 3%. Different genetic groups within both genotypes were detected at variable levels. A 180-nucleotide duplication was first characterized within the G gene in nine cases, mostly related to lower respiratory-tract infection. Conclusion: This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features.
Original languageEnglish
Pages (from-to)565-571
JournalFuture Microbiology
Volume12
Issue number7
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • G protein
  • duplication
  • evolution
  • genetic diversity
  • genotype
  • human metapneumovirus
  • molecular epidemiology
  • respiratory tract infection
  • respiratory virus
  • surveillance

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