Novel Fe<inf>3</inf>O<inf>4</inf>@GNF@SiO<inf>2</inf> nanocapsules fabricated through the combination of an: In situ formation method and SiO<inf>2</inf> coating process for magnetic resonance imaging

Changyong Lu, Stefania Sandoval, Teresa Puig, Xavier Obradors, Gerard Tobias, Josep Ros, Susagna Ricart

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

© The Royal Society of Chemistry 2017. An in situ approach for the synthesis of Fe3O4 nanoparticles combined with a SiO2 coating process was employed to prepare Fe3O4@GNF@SiO2 nanocapsules. Graphitised nanofibres (GNF) were initially filled with iron(iii) acetylacetonate, and used as a precursor for the synthesis of ultrasmall Fe3O4 nanoparticles (4.6 nm in diameter) inside the cavities of GNF (Fe3O4@GNF) with a high density. By using a silica coating process, Fe3O4@GNF@SiO2 nanocapsules were obtained. The presence of the silica shell not only prevented leakage of the nanoparticles from inside the GNF but also protected the magnetite nanoparticles from dissolution, even in harsh acidic conditions. Furthermore, the silica coating resulted in an increased dispersability of the nanocomposites in water. Magnetic resonance imaging (MRI) studies indicate relatively high relaxivities for Fe3O4@GNF nanocomposites and Fe3O4@GNF@SiO2 nanocapsules revealing the potential application of these hybrid materials for bioimaging. Therefore, the coating of filled GNF with silica is as an excellent strategy for the protection of encapsulated payloads.
Original languageEnglish
Pages (from-to)24690-24697
JournalRSC Advances
Volume7
Issue number40
DOIs
Publication statusPublished - 1 Jan 2017

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