TY - JOUR
T1 - Notch, Wnt, and Hedgehog pathways in rhabdomyosarcoma: From single pathways to an integrated network
AU - Roma, Josep
AU - Almazán-Moga, Anna
AU - Sánchez De Toledo, Josep
AU - Gallego, Soledad
PY - 2012/4/19
Y1 - 2012/4/19
N2 - Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children. Regarding histopathological criteria, RMS can be divided into 2 main subtypes: embryonal and alveolar. These subtypes differ considerably in their clinical phenotype and molecular features. Abnormal regulation or mutation of signalling pathways that regulate normal embryonic development such as Notch, Hedgehog, and Wnt is a recurrent feature in tumorigenesis. Herein, the general features of each of the three pathways, their implication in cancer and particularly in RMS are reviewed. Finally, the cross-talking among these three pathways and the possibility of better understanding of the horizontal communication among them, leading to the development of more potent therapeutic approaches, are discussed. © 2012 Josep Roma et al.
AB - Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children. Regarding histopathological criteria, RMS can be divided into 2 main subtypes: embryonal and alveolar. These subtypes differ considerably in their clinical phenotype and molecular features. Abnormal regulation or mutation of signalling pathways that regulate normal embryonic development such as Notch, Hedgehog, and Wnt is a recurrent feature in tumorigenesis. Herein, the general features of each of the three pathways, their implication in cancer and particularly in RMS are reviewed. Finally, the cross-talking among these three pathways and the possibility of better understanding of the horizontal communication among them, leading to the development of more potent therapeutic approaches, are discussed. © 2012 Josep Roma et al.
UR - https://ddd.uab.cat/record/184832
U2 - https://doi.org/10.1155/2012/695603
DO - https://doi.org/10.1155/2012/695603
M3 - Review article
VL - 2012
JO - Sarcoma
JF - Sarcoma
SN - 1357-714X
M1 - 695603
ER -
