Nosocomial transmission of hepatitis C virus during contrast-enhanced computed tomography scanning

Josep Quer, Juan Ignacio Esteban, Josep Maria Sánchez, Teresa Otero, Cristina Rius, Mar Coll, Maria Cubero, Gina Moreno, Antonio Gonzalez, Josep Vaque, Rafael Esteban, Magda Campins, Helena Pañella, Jaume Guardia, Maria Martell

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16 Citations (Scopus)

Abstract

We have investigated two cases of acute hepatitis C that occurred in patients who underwent digestive endoscopy and contrast-enhanced computed tomography (CT) scanning at two different centers. Investigations to identify the sources of infection included an on-site review of diagnostic procedures, interview of the involved healthcare staff, serological testing of the patients who underwent the procedures before and after the index cases and a molecular analysis of viral isolates from the patients and from potential viremic sources. In both cases, the epidemiological investigation identified a chronic hepatitis C virus (HCV) carrier who had been subjected to CT-scanning immediately before the index patient. Genetic distance and molecular phylogenetic analyzes of HCV sequences showed a close relationship between the isolates from these carriers and those from the acute-hepatitis patients, strongly suggesting that patient-to-patient transmission had occurred during CT. This is the first report describing two well documented cases of HCV nosocomial patient-to-patient transmission during contrast-enhanced CT scanning. © 2008 Lippincott Williams & Wilkins, Inc.
Original languageEnglish
Pages (from-to)73-78
JournalEuropean Journal of Gastroenterology and Hepatology
Volume20
Issue number1
DOIs
Publication statusPublished - 1 Jan 2008

Keywords

  • Computed tomography
  • Hepatitis C virus
  • Nosocomial transmission

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