Abstract
Norepinephrine induces a rapid and concentration-dependent rise (EC50= 1.21 ± 0.33 μM) in cyclic GMP levels in astrocyte-enriched cultures from rat brain. The response is partially mediated by α1-adrenoceptors since a marked inhibitory observed in the presence of prarosin while the ß-antagonist propranolol shows a smaller effect and the α2-antagonist yohimbine is ineffective l-NG-methylarginine, an inhibitor of nitric oxide synthesis from l-arginine, blocks the norepinephrine-induced cyclic GMP accumulation. This effect is reversed by l-arginine. © 1991.
Original language | English |
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Pages (from-to) | 343-346 |
Journal | European Journal of Pharmacology: Molecular Pharmacology |
Volume | 206 |
DOIs | |
Publication status | Published - 25 Apr 1991 |
Keywords
- Astrocytes
- Cyclic GMP
- Nitric oxide (NO)
- Norepinephrine