Noninvasive diagnosis of liver fibrosis in patients with HIV infection and HCV/HBV co-infection

S. Moreno, J. García-Samaniego, A. Moreno, E. Ortega, J. A. Pineda, J. Del Romero, C. Tural, M. A. Von Wichmann, J. Berenguer, Á Castro, R. Espacio

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Summary. The measurement of fibrosis stage critically affects the identification of the progression of liver disease, the establishment of a prognosis and therapeutic decision making. Liver biopsy has been the single, most useful method to determine the degree of liver fibrosis (LF), but with recognized limitations, mainly associated with its invasiveness. In recent years, alternative noninvasive methods have been developed, including imaging methods, such as transient elastometry, and assays based on serum biomarkers. This article reviews the available studies evaluating the value of various noninvasive methods for the assessment of LF in patients with HIV-infection and HBV/HCV co-infection, and makes recommendations on how to best use and combine them in clinical practice. © 2009 Blackwell Publishing Ltd.
Original languageEnglish
Pages (from-to)249-258
JournalJournal of Viral Hepatitis
Issue number4
Publication statusPublished - 1 Apr 2009


  • Elastometry
  • HIV/HCV co-infection
  • Liver biopsy
  • Liver fibrosis
  • Serum markers


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