Non-detectable Chlamydophila pneumoniae DNA in peripheral leukocytes in type 2 diabetes mellitus patients with and without carotid atherosclerosis

Jordi L. Reverter, Dolors Tssies, Núria Alonso, Silvia Pellitero, Anna Sanmartí, Juan Carlos Reverter

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    Abstract

    Background and objective: To study Chlamydophila pneumoniae DNA (CP-DNA) in leukocytes measured by real-time polymerase chain reaction (PCR) in patients with type 2 diabetes mellitus (DM2) with different degrees of atherosclerosis, a cross-sectional protocol was performed. Patients and methods: We included 135 patients with DM2. Clinical, metabolic and inflammatory variables were measured. Previous clinical macrovascular disease was recorded and carotid ultrasound and real-time PCR for CP-DNA were performed. Results: Mean age was 62 (7) years and mean diabetes duration 16 (9) years; 40.7% of patients presented clinical atherosclerosis, 32.5% subclinical atherosclerosis and 26.6% no evidence of atherosclerosis. Anthropometric data were homogeneous in the three groups. Patients with clinical atherosclerosis had greater carotid intima-media thickness compared to the other two groups. No CP-DNA was detected in any patient. Conclusions: The lack of detection of CP-DNA in blood leukocytes suggests that C. pneumoniae plays no active, systemic role in the pathogenesis of atherosclerosis in DM2 patients and is not a reliable marker of atherosclerosis in high-risk patients. © 2010 Elsevier España, S.L. All rights reserved.
    Original languageEnglish
    Pages (from-to)11-14
    JournalMedicina Clinica
    Volume138
    Issue number1
    DOIs
    Publication statusPublished - 21 Jan 2012

    Keywords

    • Carotid atherosclerosis
    • Chlamydophila pneumoniae
    • Type 2 diabetes

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    Reverter, J. L., Tssies, D., Alonso, N., Pellitero, S., Sanmartí, A., & Reverter, J. C. (2012). Non-detectable Chlamydophila pneumoniae DNA in peripheral leukocytes in type 2 diabetes mellitus patients with and without carotid atherosclerosis. Medicina Clinica, 138(1), 11-14. https://doi.org/10.1016/j.medcli.2011.02.029